Article Figures & Data
Figures
- FIGURE 1.
Positioning of 3-cm-diameter volume of interest (VOI) for CV calculation.
- FIGURE 2.
Flow chart to achieve low-dose and task-specific protocols.
- FIGURE 3.
CRCmax for OSEM3D, PSF7, and PSF2-EQ* protocols.
- FIGURE 4.
Quantification variability (A) and HBI (B) vs. image noise. Plots represent CV generated from acquisitions of groups B, C, and D. Dashed lines represent limits of acceptability for Qvar (A) and HBI (B), where a CV of 15% is the EARL reference.
- FIGURE 5.
Comparison of CV between PSF7 and OSEM3D. Dashed line indicates OSEM3D and PSF2 noise obtained from formulations in reference 24.
- FIGURE 6.
Plot of liver noise (CV) vs. acquisition parameter for patient data from step 2 using PSF7. Curves fit to these liver data (solid line) and to phantom data (dashed line) were generated with fitting coefficient of a = 0.77, b = −0.40, R2 = 0.67, and a = 1.40, b = −0.49, R2 = 0.98 for liver and phantom, respectively.
- FIGURE 7.
Dose scheme illustration. Injected activity is shown for 60-min uptake time and normalized to 3-min duration per bed acquisition.
Tables
Acquisition parameter OSEM3D PSF7 PSF2-EQ6 PSF2-EQ6.5 PSF2-EQ7 Group A: 1,272 MBq⋅s/kg 1.02 1.13 1.08 1.13 Group B: 416 MBq⋅s/kg 1.00 1.00 1.17 1.02 1.06 Group C: 216 MBq⋅s/kg 1.00 1.01 1.20 1.06 1.12 Group D: 81 MBq⋅s/kg 1.29 1.02 1.40 1.18 1.15 Body mass Parameter Equation 50 kg 75 kg 100 kg PSF7 A⋅t = 260⋅m 106 MBq 158 MBq 211 MBq PSF2 (24) A⋅t = 41⋅m1.48 111 MBq 189 MBq 300 MBq OSEM3D (24) A⋅t = 12⋅m1.82 126 MBq 244 MBq 426 MBq A = activity at scan time (MBq); t = acquisition duration (s); m = body mass.
Coefficients α and β (Eq. 7) for OSEM3D and PSF2 were determined through regression of data from Table V in reference 24. Injected activity is decay-corrected for 60 min before scan time and typical 3-min acquisition duration per bed position.
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