The medical isotope crisis: how we got here and where we are going

TJ Ruth - Journal of nuclear medicine technology, 2014 - Soc Nuclear Med
99mTc is the most widely used radionuclide in nuclear medicine. The reactor stoppages that
occurred in recent years illustrated the vulnerability of the availability of radiotracers for …

[HTML][HTML] The options for the future production of the medical isotope 99Mo

SC Van der Marck, AJ Koning, KE Charlton - European journal of nuclear …, 2010 - Springer
There is a shortage of medical isotopes in the world today. Two of the most important isotope
producing reactors, the National Research Universal (NRU) reactor in Canada and the High …

Potential ways to address shortage situations of 99Mo/99mTc

LM Filzen, LR Ellingson, AM Paulsen… - Journal of nuclear …, 2017 - Soc Nuclear Med
99mTc, the most common radioisotope used in nuclear medicine, is produced in a nuclear
reactor from the decay of 99Mo. There are only a few aging nuclear reactors around the …

Sustained availability of 99mTc: possible paths forward

MRA Pillai, A Dash, FFR Knapp - Journal of Nuclear Medicine, 2013 - Soc Nuclear Med
The availability of 99mTc for single-photon imaging in diagnostic nuclear medicine is crucial,
and current availability is based on the 99Mo/99mTc generator fabricated from fission-based …

[HTML][HTML] 99Mo supply—the times they are a-changing

DM Lewis - European journal of nuclear medicine and molecular …, 2009 - Springer
Recently there has been a phenomenal growth in clinical PET using 18FDG as well as a
resurgence of interest in imaging with 123I. However, 99mTc still remains the most popular …

[PDF][PDF] Accelerator production options for 99Mo

K Bertsche - Proceedings of IPAC, 2010 - researchgate.net
Shortages of 99Mo, the most commonly used diagnostic medical isotope, have caused great
concern and have prompted numerous suggestions for alternate production methods. A …

99Mo shortage in nuclear medicine: crisis or challenge?

JR Ballinger - Journal of Labelled Compounds and …, 2010 - infona.pl
Reactor produced 99 Mo is the source of 99m Tc used in 85% of nuclear medicine studies
but the worldwide supply is currently very fragile. This has forced radiopharmaceutical …

Reduce, reuse and recycle: A green solution to Canada's medical isotope shortage

R Galea, C Ross, RG Wells - Applied Radiation and Isotopes, 2014 - Elsevier
Due to the unforeseen maintenance issues at the National Research Universal (NRU)
reactor at Chalk River and coincidental shutdowns of other international reactors, a global …

Diversification in the supply chain of 99Mo ensures a future for 99mTc

CS Cutler, SW Schwarz - Journal of Nuclear Medicine, 2014 - Soc Nuclear Med
The uncertain availability of 99mTc has become a concern for nuclear medicine
departments across the globe. An issue for the United States is that currently it is dependent …

Assessment of radionuclidic impurities in cyclotron produced 99mTc

O Lebeda, EJ van Lier, J Štursa, J Ráliš… - Nuclear medicine and …, 2012 - Elsevier
INTRODUCTION: The commercial viability of cyclotron-produced 99mTc as an alternative to
generator-produced 99mTc depends on several factors. These include: production yield …