[HTML][HTML] Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood–Brain Barrier Permeability in Mice
A Mizutani, M Kobayashi, M Ohuchi, K Sasaki… - Pharmaceutics, 2022 - mdpi.com
Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive
ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs …
ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs …
Differences in accumulation and the transport mechanism of l-and d-methionine in high-and low-grade human glioma cells
M Kobayashi, A Mizutani, K Nishi, S Nakajima… - Nuclear Medicine and …, 2017 - Elsevier
Introduction Although [S-methyl-11C]-labeled L-methionine and D-methionine ( 11 CL-MET
and 11 CD-MET) are useful radiotracers for positron emission tomography imaging of brain …
and 11 CD-MET) are useful radiotracers for positron emission tomography imaging of brain …
[HTML][HTML] Comparison of L-and D-amino acids for bacterial imaging in lung infection mouse model
Y Muranaka, A Mizutani, M Kobayashi… - International Journal of …, 2022 - mdpi.com
The effectiveness of L- and D-amino acids for detecting the early stage of infection in bacterial
imaging was compared. We evaluated the accumulation of 3 HL-methionine (Met), 3 HD-…
imaging was compared. We evaluated the accumulation of 3 HL-methionine (Met), 3 HD-…
Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan
…, H Okudaira, M Ono, T Tsujiuchi, A Mizutani… - Nuclear Medicine and …, 2014 - Elsevier
Introduction In clinical hepatobiliary scintigraphy, 99m Tc-N-pyridoxyl-5-methyltryptophan (
99m Tc-PMT) is an effective radiotracer among the 99m Tc-pyridoxylaminates. However, the …
99m Tc-PMT) is an effective radiotracer among the 99m Tc-pyridoxylaminates. However, the …
Performance evaluation of the eXplore speCZT preclinical imaging system
…, Y Miyazaki, M Kobayashi, K Nishi, A Mizutani… - Annals of nuclear …, 2014 - Springer
Objective The eXplore speCZT is a recently introduced cadmium zinc telluride-based
preclinical SPECT system that has a stationary detector design with interchangeable rotating …
preclinical SPECT system that has a stationary detector design with interchangeable rotating …
[HTML][HTML] Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine
A Mizutani, M Kobayashi, R Aibe, Y Muranaka… - International Journal of …, 2022 - mdpi.com
Drug metabolizing enzyme activity is affected by various factors such as drug–drug interactions,
and a method to quantify drug metabolizing enzyme activity in real time is needed. In …
and a method to quantify drug metabolizing enzyme activity in real time is needed. In …
Different Efflux Transporter Affinity and Metabolism of 99mTc-2-Methoxyisobutylisonitrile and 99mTc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer
M Kobayashi, T Tsujiuchi, Y Okui, A Mizutani… - Pharmaceutical …, 2019 - Springer
Background Little is known about the affinity and stability of 99m Tc-labeled 2-methoxyisobutylisonitrile
( 99m Tc-MIBI) and tetrofosmin ( 99m Tc-TF) for imaging of multiple drug …
( 99m Tc-MIBI) and tetrofosmin ( 99m Tc-TF) for imaging of multiple drug …
Simultaneous acquisition of 99mTc- and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors
M Kobayashi, I Matsunari, K Nishi, A Mizutani… - Annals of nuclear …, 2016 - Springer
Objective Simultaneous acquisition of 99m Tc and 123 I was evaluated using a preclinical
SPECT scanner with cadmium zinc telluride (CZT)-based detectors. Methods 10-ml cylindrical …
SPECT scanner with cadmium zinc telluride (CZT)-based detectors. Methods 10-ml cylindrical …
[HTML][HTML] Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice
Y Muranaka, M Matsue, A Mizutani… - International Journal of …, 2023 - mdpi.com
The World Health Organization has cautioned that antimicrobial resistance (AMR) will be
responsible for an estimated 10 million deaths annually by 2050. To facilitate prompt and …
responsible for an estimated 10 million deaths annually by 2050. To facilitate prompt and …
[131I] MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I] MIBG in neuroblastoma
M Kobayashi, A Mizutani, K Nishi, Y Muranaka… - Nuclear Medicine and …, 2020 - Elsevier
… Author links open overlay panel Masato Kobayashi a , Asuka Mizutani a , Kodai Nishi b , Yuka
Muranaka … Asuka Mizutani and Kodai Nishi performed biodistribution and SPECT imaging. …
Muranaka … Asuka Mizutani and Kodai Nishi performed biodistribution and SPECT imaging. …