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Dextrose Solutions Yield Radiochemical Impurities: The "Sweet" Scans

Eman Al-Enizi, MD;, Nafisah Kazem, MD;, Azu Owunwanne, PhD;, B. David Collier, MD; and Mercy Mathew, MA

Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait



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  		FIGURE 1. Anterior-view 99mTc-stannous colloid image shows unexpected findings of significant kidney, bladder, cardiac blood- pool, and soft-tissue background activity indicating altered biodistribution as well as uptake in liver and spleen.

 


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  		FIGURE 2. Whole-body anterior- and posterior-view 99mTc-MDP images show unexpected findings of significant kidney, bladder, cardiac blood-pool, gallbladder, and soft-tissue background activity.

 


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  		FIGURE 3. Series of 4 anterior-view images over first 10 min after injection of 99mTc-mebrofenin in patient with normal liver function. Images show reduced liver uptake with no excretion into bile ducts and significant kidney, cardiac blood-pool, and soft-tissue background activity.

 


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  		FIGURE 4. Saline chromatograms of 99mTc-MDP preparations for which 99mTc-pertechnetate was diluted with either normal saline (A) or 5% dextrose (B). Notice that preparation B contains radiopharmaceutical impurities that do not migrate with solvent front.

 




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