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Detecting Regional Cerebral Blood Flow Changes in Alzheimer’s Patients After Milameline Treatment: Activation or Baseline SPECT?

School of Clinical Sciences, Faculty of Health Studies, Charles Sturt University, Wagga Wagga, New South Wales, Australia

View larger version (70K): [in a new window]   FIGURE 1. Increased rCBFs caused by cognitive activation before milameline. Talairach coordinates of these activation regions are listed in Table 1. Similar pattern of increased rCBFs was observed in activation after medication (not shown).

View larger version (38K): [in a new window]   FIGURE 2. Decreased rCBFs caused by cognitive activation before (A) and after (B) milameline. Talairach coordinates are (4, -30, 12) and (4, -42, 12) before and (-16, -36, 12) after medication. T scores are 4.60, 4.26, and 5.93, respectively (P < 0.001).

View larger version (52K): [in a new window]   FIGURE 3. Decreased rCBFs obtained from contrast of activation images after milameline. Talairach coordinates are (-62, -18, -18), (62, -14, -16), and (-46, -54, 32) with T scores of 5.51, 5.26, and 3.99, respectively (P < 0.001). No statistically significant increase in rCBF was evident after medication.