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First published online February 17, 2009, 10.2967/jnmt.108.050732
doi:10.2967/jnmt.108.050732
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Journal of Nuclear Medicine Technology Volume 37, Number 1, 2009 57-59
© 2009 by Society of Nuclear Medicine

Kinevac Stability After Reconstitution with Sodium Chloride Injection USP, 0.9%

Latisha T. Littleton1, Bader B. Fileta2, Robert Massey3 and Timothy I. Wood2

1 Department of Pharmacy, Walter Reed Army Medical Center, Washington, DC; 2 Department of Clinical Investigation, Walter Reed Army Medical Center, Washington, DC; and 3 Department of Nuclear Medicine, Walter Reed Army Medical Center, Washington, DC

Correspondence: For correspondence or reprints contact: Latisha Littleton, 366-C Reno Rd., Honolulu, HI 96819. E-mail: Latisha.t.littleton{at}us.army.mil

ABSTRACT

Our objective was to compare the stability of Kinevac when reconstituted with sodium chloride injection, USP, 0.9%, versus the manufacturer's recommended sterile water for injection, USP, and to determine the effects on stability of deviating from the manufacturer's recommended methods of product preparation. Methods: Kinevac was reconstituted with either sterile water or 0.9% sodium chloride. Triplicate high-performance liquid chromatography was performed on each vial of reconstituted sample at time zero and at time zero plus 8 h. The concentration of each sample, as measured by the peak area, was recorded at each time point. The process was repeated over 4 consecutive days. Results: Kinevac reconstituted with sterile water resulted in the recovery of 89.73% of the time zero concentration after 8 h. Kinevac reconstituted with 0.9% sodium chloride resulted in chemical stability of the injection, with 80.05% recovery of the time zero value after 8 h. Conclusion: Kinevac is more stable when reconstituted with sterile water than when reconstituted with 0.9% sodium chloride. Kinevac should be reconstituted with sterile water for injection as per the manufacturer's instructions.

Key Words: stability, Kinevac; sincalide; Hida Scan; CCK






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