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Journal of Nuclear Medicine Technology Volume 32, Number 4, 2004 179-187
© 2004 by Society of Nuclear Medicine

Gated Myocardial Perfusion SPECT: Basic Principles, Technical Aspects, and Clinical Applications

Asit K. Paul, MBBS, PhD and Hani A. Nabi, MD, PhD

Department of Nuclear Medicine, State University of New York, University at Buffalo, Buffalo, New York

ABSTRACT

Electrocardiographically gated myocardial perfusion SPECT (GSPECT) is a state-of-the-art technique for the combined evaluation of myocardial perfusion and left ventricular function within a single study. It is currently one of the most commonly performed cardiology procedures in a nuclear medicine department. Automation of the image processing and quantification has made this technique highly reproducible, practical, and user friendly in the clinical setting. In patients with coronary artery disease, gating enhances the diagnostic and prognostic capability of myocardial perfusion imaging, provides incremental information over the perfusion data, and has shown potentials for myocardial viability assessment and sequential follow-up after therapy. After reading this article, the readers will understand (a) the general principles of GSPECT and quantitation, (b) the methods of the image acquisition and analysis, (c) validation of GSPECT with other cardiac imaging modalities, and (d) application of the GSPECT-derived functional parameters in the clinical practice.

Key Words: cardiology; electrocardiographic gating; gated myocardial perfusion SPECT; left ventricular function




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