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Detection of Musculoskeletal Infection with ¹⁸F-FDG PET: Review of the Current Literature

¹ Department of Radiology, Medical University of South Carolina, Charleston, South Carolina;
² Department of Orthopedics, Medical University of South Carolina, Charleston, South Carolina

There are several studies on ¹⁸F-FDG PET in the evaluation of musculoskeletal infection; however, a search of the literature failed to identify any large-scale studies. The 7 articles reviewed included 273 cases of suspected musculoskeletal infection evaluated by ¹⁸F-FDG PET. This method was found to be sensitive and specific in the evaluation of chronic and acute osteomyelitis and prosthetic infection. Furthermore, ¹⁸F-FDG PET was accurate in the evaluation of infection at previous surgical sites even within 12 mo of surgery. The current literature suggests that ¹⁸F-FDG PET is a highly accurate method to detect musculoskeletal infection.

Key Words: bone; infectious disease; ¹⁸F-FDG PET; arthroplasty; musculoskeletal infection; osteomyelitis