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Journal of Nuclear Medicine Technology Volume 31, Number 4, 2003 206-209
© 2003 by Society of Nuclear Medicine

LABORATORY METHODS

Measurement of 18F-FDG Concentrations in Blood Samples: Comparison of Direct Calibration and Standard Solution Methods

Henri N.J.M. Greuter1, Ronald Boellaard, PhD1, Arthur van Lingen, PhD1, Eric J.F. Franssen, PharmD, PhD1,2 and Adriaan A. Lammertsma, PhD1

1PET Center, VU University Medical Center, Amsterdam, The Netherlands;
2Department of Pharmacy, VU University Medical Center, Amsterdam, The Netherlands

ABSTRACT

Objective: The purpose of this study was to compare the accuracy and reliability of 2 well counter methods for measuring the activity concentration of 18F-FDG in blood samples.

Methods: Three to 5 blood samples from 154 patient studies were weighed and measured in a well counter. The 18F-FDG activity concentration was derived using, first, a direct calibration factor to convert measured well counter readings into activity concentration and, second, a comparison of measured counts with those of a specified standard solution.

Results: The ratio between the activity concentration results of the 2 methods was 0.996 ± 0.033, indicating that the methods provided equal results.

Conclusion: Because the standard solution method is more prone to human error, less reproducible, and more labor intensive, preference should be given to the direct calibration method.

Key Words: blood samples; activity concentration; 18F-FDG; dose calibrator; well counter




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