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Journal of Nuclear Medicine Technology Volume 31, Number 2, 2003 76-78
© 2003 by Society of Nuclear Medicine


IMAGING

Severe Systemic Reaction to 99mTc-Methylene Diphosphonate: A Case Report

Kottekkattu K. Balan, MD1, Arabinda K. Choudhary, MBBS2, Anupama Balan, MBBS3 and Gordon Wishart, MD1

1Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom
2Departments of Radiology and Surgery, Addenbrooke’s Hospital, Cambridge, United Kingdom
3Department of Renal Medicine, Oldchurch Hospital, Essex, United Kingdom

We report an unusual severe systemic reaction that occurred in a woman after a 99mTc-methylene diphosphonate bone scan and for which no alternative explanation could be found. The bone scintigram showed diffusely increased uptake in the liver and kidneys accompanied by reversible dysfunction of these organs and dermatologic manifestations. We speculate that an immune-mediated mechanism may have caused this unusual reaction.

Key Words: 99mTc-methylene diphosphonate; bone scintigram; adverse reaction; hepatorenal dysfunction







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