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Localization of ^99mTc HMDP in an Extraskeletal Myxoid Chondrosarcoma: A Case Report

Nuclear Medicine Service and Pathology Service, Lexington VA Medical Center, Division of Nuclear Medicine, Department of Diagnostic Radiology, and Department of Pathology, University of Kentucky Medical Center, Lexington, Kentucky

Extraskeletal myxoid chondrosarcoma of the lower extremity is rare, and slowly progressive. The authors of this article present the case of a man with progressive enlargement of the right thigh that underwent bone scintigraphy. The bone images showed a diffuse, moderate increase in uptake in the swollen right thigh. Despite chemotherapy, the patient died 28 mo later. At autopsy, it was confirmed that he had extraskeletal myxoid chondrosarcoma of the right thigh, which had metastasized to the upper arms, left scapula, lungs, pleurae, and right lower quadrant of the abdomen. The myxoid chondroid matrix, a major feature of the extraskeletal myxoid chondrosarcoma, is thought to account for the localization of the bone-imaging agent.

Key Words: myxoid chondrosarcoma; bone-imaging agent; ^99mTc HMDP; lower extremity