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The Effect of Vincristine on the Biodistribution of Technetium-99m DTPA, GHA, and DMSA in Balb/c Female Mice

Instituto Nacional de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro; Instituto Nacional do Câncer, Serviço de Pisquisa Básica, Rio de Janeiro; and Universidade Federal de Minas Gerais, Faculdade de Farmácia, Minas Gerais, Brasil

Objective: Vincristine has been widely used in various chemotherapeutic protocols in oncology. The purpose of this study was to evaluate the effect of vincristine on the biodistribution of ^99mTc-DMSA, ^99mTc-GHA, and ^99mTc-DTPA in Balb/c female mice. Methods: Vincristine (0.03 mg, 0.3 mL) was injected into female isogenic Balb/c mice (n = 15), in 3 doses over an interval of 96 h. The ^99mTc-DMSA, ^99mTc-GHA, or ^99mTc-DTPA (7.4 MBq) was administered after the last dose of vincristine. After 0.5 h the animals were killed rapidly. The organs (pancreas, thyroid, brain, thymus, ovary, uterus, spleen, kidney, heart, stomach, lung, liver, bone, and lymph nodes) were isolated and the radioactivity in each organ was counted in a NaI(Tl) well counter. The percentage of radioactivity (%) in each was calculated and compared with the control group. Statistical analysis was performed by Wilcoxon test (P < 0.05). Results: The percentage of ^99mTc-DMSA was increased in the lung, pancreas, heart, thyroid, brain, bone, and lymph nodes (inguinal and mesenteric). The percentage of ^99mTc-GHA was decreased in the uterus, ovary, spleen, thymus, lymph nodes (inguinal and mesenteric), kidney, and heart. The percentage of ^99mTc-DTPA was increased in thymus, lymph nodes (inguinal and mesenteric), ovary, uterus, spleen, kidney, heart, stomach, lung, liver, and bone. Conclusion: The results could be explained by the metabolization, toxic effect, therapeutic, or immunosupressive action of the studied chemotherapeutic drug.

Key Words: technetium-99m-DMSA; technetium-99m-GHA; technetium-99m-DTPA; vincristine; drug interaction; biodistribution