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Assessing Coronary Artery Disease with Thallium-201 Rest and Technetium-99m-Sestamibi Stress Testing at Two Centers

Department of Health Physics, University of Nevada, Las Vegas; Advanced Heart Care, Las Vegas; and Cardiovascular Consultants of Nevada, Las Vegas, Nevada

Objective: In this study we assessed the specific location(s) of cardiac wall abnormalities in a population of patients referred for coronary artery disease and compared gender differences in the interpretation of nuclear medicine rest/stress results. Methods: The study group consisted of 846 patients referred to 2 nuclear medicine outpatient cardiology centers for assessment between November 1998 and April 1999. All patients received dual-isotope perfusion ²⁰¹Tl rest/^99mTc-sestamibi stress tests. A retrospective analysis of patient results was performed. Results: In both facilities the largest percentage of defects was identified in the inferior wall (35.5%), followed by the anterior wall (26.5%). Cardiac defects identified in 3 other walls were much lower: lateral wall (14.2%), septal (13.8%), and apical (9.5%). In both outpatient clinics the normalcy rate was much higher for women than men. The normalcy rate in men was 40%, whereas women demonstrated a normalcy rate of 60%. An analysis of treadmill stress versus pharmacologic stress did not illuminate the cause of this difference. Conclusion: The most common site of myocardial wall abnormalities occurred in the inferior wall followed by the anterior wall. A large disparity was identified between the results for men compared with those for women. Men had nearly twice the number of defects as women in this study.

Key Words: technetium-99m-sestamibi stress test; thallium-201 rest test; coronary artery disease; gender differences

This article has been cited by other articles:

				A. A. Elkamhawy and H. Chandna Minimum Detectable Defect Thickness in SPECT Myocardial Perfusion Test: Phantom Study with 99mTc and 201Tl J. Nucl. Med. Technol., December 1, 2001; 29(4): 183 - 188. [Abstract] [Full Text] [PDF]