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Gallium-67 Imaging in Lymphoma: Tricks of the Trade

Department of Radiology, Division of Nuclear Medicine, Oregon Health Sciences University, Portland, Oregon

Objective: Although the use of ¹⁸F-fluorodeoxyglucose (FDG) PET for evaluating lymphoma is gaining in popularity, PET is not yet universally available and large prospective comparisons between ⁶⁷Ga and ¹⁸F-FDG PET scans in predicting the long-term outcome after treatment are lacking. Scintigraphic imaging with ⁶⁷Ga remains an important tool in evaluating the response of lymphoma to therapy. There are a variety of challenges and pitfalls inherent in ⁶⁷Ga imaging for lymphoma. These are discussed and problem cases are illustrated. After reading this article, the nuclear medicine professional should be able to: (a) optimize the technical approach to and (b) maximize the diagnostic accuracy of ⁶⁷Ga scintigraphy in assessing the response of lymphoma to therapy.

Key Words: gallium-67; lymphoma; normal and abnormal uptake